Zhouxi “Josie” Wang

Graduate Student (2008-2013)

Current Institution

National Institutes of Health, Bethesda, MD

Undergraduate Institution

Donghua University, Shanghai, China

Research Projects

Computer-aided drug design for Human African Trypanosomiasis (HAT).

Molecular modeling methodology development for annotation of biochemical functions of enzymes in superfamilies.

Personal Interests

Yoga, traveling, history and new technology.

Conference Presentations

2011 – Protein Society Conference, Boston, MA
2010 – ACS National Meeting, Boston, MA
2010 – ISMB Conference Boston, MA
2009 – ASMS, Philadelphia, PA

Publications

Google Scholar

2013

The human Aurora kinase inhibitor danusertib is a lead compound for anti-trypanosomal drug discovery via target repurposing

Stefan O. Ochiana, Vidya Pandarinath, Zhouxi Wang, Rishika Kapoor, Mary Jo Ondrechen, Larry Ruben, and Michael P. Pollastri, European Journal Medicinal Chemistry, 62, 777-784 (2013)

Protein Function Annotation with Structurally Aligned Local Sites of Activity (SALSAs)

Zhouxi Wang, Pengcheng Yin, Joslynn S. Lee, Ramya Parasuram, Srinivas Somarowthu, and Mary Jo Ondrechen, BMC Bioinformatics, 14 (Suppl 3):S13 (2013)

2011

Pharmacological Validation of Trypanosoma brucei Phosphodiesterases B1 and B2 as Druggable Targets for African Sleeping Sickness

Nicholas D. Bland, Cuihua Wang, Craig Tallman, Alden E. Gustafson, Zhouxi Wang, Trent D. Ashton, Stefan Ochiana, Gregory McAllister, Kristina Cotter, Anna P. Fang, Lara Gechijian, Norman Garceau, Rajiv Gangurde, Ron Ortenberg, Mary Jo Ondrechen, Robert K. Campbell, and Michael P. Pollastri, Medicinal Chemistry 54 (23), 8188-8194 (2011)

2010

Desulfurization of Cysteine-Containing Peptides Resulting from Sample Preparation for Protein Characterization by MS

Zhouxi Wang, Tomas Rejtar, Zhaohui Sunny Zhou and Barry L. Karger, Rapid Communications in Mass Spectrometry, 24 (3):267-275 (2010)

2009

TAT Peptide and Its Conjugates: Proteolytic Stability

Jacob Grunwald, Tomas Rejtar, Rupa Sawant, Zhouxi Wang, Vladimir P. Torchilin, Bioconjugate Chemistry, 20 (8): 1531–1537 (2009)

2007

Facile preparation of pH-responsive gelatin-based core–shell polymeric nanoparticles at high concentrations via template polymerization

Youwei Zhang, Zhouxi Wang, Yansong Wang, Jiongxin Zhao and Chengxun Wu, Polymer, 48 (19): 5639-5645 (2007)

2006

A Way to Prepare Core-Shell Biocompatible Polymeric Nano-particles from Gelatin and Acrylic acid

Zhouxi Wang, Youwei Zhang, Yansong Wang, Jiongxin Zhao, Chengxun Wu, Journal of Macromolecular Science, 43 (11): 1779-1786 (2006)

2005

pH Responsive Core-Shell Particles and Hollow Sphere Attained by Macro molecular Self-Assembly

Youwei Zhang, Ming Jiang, Jiongxin Zhao, Zhouxi Wang, Hongjin Dou, Daoyun Chen, Langmuir, 21 (4): 1531-1538 (2005)